ABSTRACT
Objective: to measure differences of platelet indices in subjects with and without diabetes mellitus and hypertension
Methodology: this was a cross-sectional analysis from Jan-11 to Feb-2012. From a target population of non-pregnant adult subjects being advised a fasting blood glucose or OGTT for confirming or excluding diabetes, we finally selected 820 individuals for inclusion into study. Fifty known diabetics were also included in the study. Subjects were formally interviewed and sampled for fasting blood glucose, and platelet indices [including platelet count, platecrit [PCT], mean platelet volume [MPV] and platelet distribution [PDW]. The results of platelet indices were compared between 4 groups based on OGTT. Platelet indices were also compared between groups based upon post-load glycemic status and hypertension
Results: age and MPV showed slight positive and significant correlations with fasting blood. [Age: r2=0.117 [p<0.001] and MPV: r2=0.116 [P=0.001]; other platelet indices did not show significant correlations. Out of the 4 platelet indices studied, MPV and PCT were found to significantly increase from normoglycemia to individuals with established diabetes mellitus in one way ANOVA analysis. Subjects demonstrating post load hyperglycemia [n=47] had higher mean platelet volumes than individuals having post load normoglycemia [n=30] [MPV: 9.63 + 1.51vs 8.90 + 0.98, p=0.012]. Hypertensive subjects did not demonstrate higher MPV results than normotensive subjects in our study
Conclusion: mean platelet volume and platecrit increases across various grades of hyperglycemia. However, the changes become quite prominent in subjects having established diabetes with marked hyperglycemia. Post load hyperglycemia was more predictive of rises in mean platelet volumes
ABSTRACT
To compare platelet indices among patients with low and high levels of cholesterolemia and triglyceridemia. This cross-sectional study was conducted from January 2011to May 2012 at the departments of pathology, PNS Rahat and Baqai medical and dental university, Karachi. A total of 867 subjects presenting for estimation of fasting triglycerides and total cholesterol were selected after excluding patients receiving anti-platelet or lipid medication, pregnancy, acute in factious disorders. They were interviewed, examined and sampled for measurement of total cholesterol, triglycerides and platelet indices including total platelet count, mean platelet volume [MPV], platelet distribution width [PDW] and platecrit [PCT]. The results of platelet count and mean platelet volume were found to be significantly different among subjects with normal cholesterolemia [<5.2mmol/L], borderline raised cholesterol group [5.2-6.3 mmol/L] and hypercholesterolemia [>6.3 mmol/L]; however, post-hoc comparison did not show any significant difference between all groups. Using age as a variable and segregating total cholesterol results into 7 groups, starting from very low cholesterol values [<4.0 mmol/L] to highest [>6.5 mmol/L], in a univariate general linear model, higher mean platelet volume were observed at the extremes of cholesterolemia groups [p=0.039]. A similar trend was observed for platelet count after adjusting for age, where low levels of platelet levels were associated with hypocholesterolemia and hypercholesterolemia [p=0.021]. Higher MPV and low total platelet counts were associated with the observed extremes of cholesterol range. No significant differences were observed for platelet indices across various groups formulated based upon fasting triglycerides